2,3-二氢-1H-异吲哚-5-基甲醇合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=50°C; P=3102.97 Torr; 30 h;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44041 A1, 2008 ;
Location in patent: Page/Page column 298-299 ;
反应条件
hydrogenchloride in methanol T=20°C; 12 h;
参考文献
Horiuchi, Takao; Nagata, Motoko; Kitagawa, Mayumi; Akahane, Kouichi; Uoto, Kouichi
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 23 p. 7850 - 7860
反应条件
1: LiAlH4 / tetrahydrofuran / 25 °C 2: 86 percent / H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: NBS; benzoyl peroxide / CCl4 / Heating 2: Et3N / benzene / Heating 3: LiAlH4 / tetrahydrofuran / 25 °C 4: 86 percent / H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: Et3N / benzene / Heating 2: LiAlH4 / tetrahydrofuran / 25 °C 3: 86 percent / H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
triethylamine in dichloromethane T=25°C;
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: 2.49 g / K2CO3 / methanol; H2O / 6 h / 20 °C 2: 78 percent / dimethylsulfoxide; trifluoroacetic anhydride; N,N-diisopropylethylamine / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Fray, M. Jonathan; Allen, Paul; Bradley, Paul R.; Challenger, Clare E.; Closier, Michael; Evans, Tim J.; Lewis, Mark L.; Mathias, John P.; Nichols, Carly L.; Po-Ba, Yvonne M.; Snow, Hayley; Stefaniak, Mark H.; Vuong, Hannah V.
Tetrahedron, 2006 , vol. 62, # 29 p. 6869 - 6875
