8-氯-6,7-二氟-1-[(1r,2s)-2-氟环丙基]-1,4-二氢-4-氧代-3-喹啉羧酸合成路线 (共 2 条)
反应条件
hydrogenchloride T=110°C; 2.5 h;
参考文献
Kimura; Atarashi; Kawakami; Sato; Hayakawa
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3344 - 3352
反应条件
1: Et3N / acetonitrile / 5 h / Heating 2: 35percent HCl / 0.25 h / Ambient temperature View Scheme
参考文献
Kimura; Atarashi; Kawakami; Sato; Hayakawa
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3344 - 3352