(7S)-5-氮杂螺[2.4]庚烷-7-基氨基甲酸叔丁酯合成路线 （共 11 条）
反应条件
hydrogen; 5 percent palladium-carbon in ethanol P=3192 Torr; 6 h;
参考文献
Kimura; Atarashi; Kawakami; Sato; Hayakawa
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3344 - 3352
反应条件
1: 67 percent / tetrahydrofuran / 4 h 2: 46 percent / H2 / 50percent aq. 5percent Pd/C / ethanol / 6 h / 3192 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3344 - 3352
反应条件
1: 67 percent / tetrahydrofuran / 4 h 2: 46 percent / H2 / 50percent aq. 5percent Pd/C / ethanol / 6 h / 3192 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3344 - 3352
反应条件
1: 80 percent / lithium aluminium hydride / tetrahydrofuran / 17 h / Heating 2: 67 percent / tetrahydrofuran / 4 h 3: 46 percent / H2 / 50percent aq. 5percent Pd/C / ethanol / 6 h / 3192 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 20 p. 3344 - 3352
反应条件
1: 92 percent / toluene / 18 h / Ambient temperature 2: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 4 p. 587 - 590
反应条件
1: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h 2: 92 percent / toluene / 18 h / Ambient temperature 3: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 4 p. 587 - 590
反应条件
1: 92 percent / toluene / 18 h / Ambient temperature 2: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 4 p. 587 - 590
反应条件
1: 65 percent / 0.1percent aq. K2HPO4/KH2PO4 buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880 2: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h 3: 92 percent / toluene / 18 h / Ambient temperature 4: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 4 p. 587 - 590
反应条件
1: toluene / 0.5 h / Heating 2: 65 percent / 0.1percent aq. K2HPO4/KH2PO4 buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880 3: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h 4: 92 percent / toluene / 18 h / Ambient temperature 5: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 4 p. 587 - 590
反应条件
1: trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature 2: toluene / 0.5 h / Heating 3: 65 percent / 0.1percent aq. K2HPO4/KH2PO4 buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880 4: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h 5: 92 percent / toluene / 18 h / Ambient temperature 6: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 4 p. 587 - 590
