反应条件
1.1: tetrahydrofuran / -78 - 25 °C
2.1: 2,6-di-tert-butyl-4-methyl-phenol / [Cu(I)(CH3CN)4]PF6; (S,S)-i-Pr-FOXAP / tetrahydrofuran / -78 °C / Inert atmosphere
2.2: -78 °C
3.1: hydrogen; acetic acid / 5 Pd(II)/C(eggshell) / ethanol / 2 h / 15 - 20 °C / 2585.81 Torr / Inert atmosphere
3.2: 24 h / 15 - 20 °C
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; ZAJAC, Matthew, Allen
Patent: WO2011/29762 A1, 2011 ;
WO 2011/029762 A1
