1: With water; sodium hydroxide in dichloromethane T=25°C; 2: With hydrogenchloride in dichloromethane; water 0.5 h; Product distribution / selectivity;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ZHANG, Beili; KRAWIEC, Mariusz; LUISI, Brian; MEDEK, Ales
Patent: WO2011/50220 A1, 2011 ;
Location in patent: Page/Page column 41 ;
WO 2011/050220 A1
