(R)-1-(叔丁氧基羰基)-3-吡咯烷-甲磺酸酯合成路线 （共 15 条）
反应条件
triethylamine in dichloromethane T=20°C; Cooling with ice;
参考文献
F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; BURDICK, Daniel Jon; CHAMBERS, Mark; CHEN, Huifen; ESTRADA, Anthony; SWEENEY, Zachary Kevin; CHAN, Bryan K.
Patent: WO2012/62783 A1, 2012 ;
Location in patent: Page/Page column 75 ;
WO 2012/062783 A1
反应条件
pyridine in dichloromethane T=0 - 50°C; 8.25 h;
参考文献
SANOFI-AVENTIS
Patent: WO2007/93363 A1, 2007 ;
Location in patent: Page/Page column 88 ;
WO 2007/093363 A1
反应条件
1: 86 percent / H2 / Pearlmans catalyst / methanol; H2O / 2 h / 2068.59 Torr 2: Et3N / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Castro; Street; Guiblin; Jelley; Russell; Sternfeld; Beer; Stanton; Matassa
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3497 - 3500
反应条件
in toluene T=3 - 14°C; Product distribution / selectivity;
参考文献
TARGACEPT, INC.; TOLER, Steven M.; HOSFORD, David A.; LIPPIELLO, Patrick M.; DUNBAR, Geoffrey Charles; CALDWELL, William Scott; HAMEDANI, Parviz; BENCHERIF, Merouane
Patent: WO2011/112428 A2, 2011 ;
Location in patent: Page/Page column 28 ;
反应条件
1: NH3 / methanol 2: pyridine / CH2Cl2 View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
1: dimethylformamide 2: NH3 / methanol 3: pyridine / CH2Cl2 View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
1: 85 percent / pyridine / CH2Cl2 / 20 °C 2: dimethylformamide / 72 h / 110 °C 3: 4.2 g / ammonia / methanol / 0 °C 4: 90 percent / pyridine / CH2Cl2 / 20 °C View Scheme
参考文献
Kocalka, Petr; Pohl, Radek; Rejman, Dominik; Rosenberg, Ivan
Tetrahedron, 2006 , vol. 62, # 24 p. 5763 - 5774
反应条件
1: 100 percent / NaHCO3 / H2O / 65 h / 20 °C 2: 98 percent / Et3N / ethyl acetate / 0.5 h / -5 °C View Scheme
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=60°C; Title compound not separated from byproducts.;
参考文献
Benard, Christophe; Mohammad, Rahim; Saraswat, Neerja; Shan, Rudong; Maiti, Samarendra N.; Wuts, Peter G. M.; Stier, Michael; Lints, Teresa; Bradow, James; Schwarz, Jacob B.
Synthetic Communications, 2008 , vol. 38, # 4 p. 517 - 524
反应条件
sodium hydride in N,N-dimethyl-formamide T=60°C; Title compound not separated from byproducts.;
参考文献
Benard, Christophe; Mohammad, Rahim; Saraswat, Neerja; Shan, Rudong; Maiti, Samarendra N.; Wuts, Peter G. M.; Stier, Michael; Lints, Teresa; Bradow, James; Schwarz, Jacob B.
Synthetic Communications, 2008 , vol. 38, # 4 p. 517 - 524
