hydrogenchloride in 1,4-dioxane 72 h; Heating;

1: 1) n-butyllithium / 1) THF, 0 deg C, 3 h; 2) THF, room temp., 2 h 2: 73 percent / tetrahydrofuran / -78 - 20 °C 3: 84 percent / 3N-aq. HCl / dioxane / 72 h / Heating View Scheme

1: 1) n-butyllithium / 1) THF, 0 deg C, 3 h; 2) THF, room temp., 2 h 2: 73 percent / tetrahydrofuran / -78 - 20 °C 3: 84 percent / 3N-aq. HCl / dioxane / 72 h / Heating View Scheme

1: 73 percent / tetrahydrofuran / -78 - 20 °C 2: 84 percent / 3N-aq. HCl / dioxane / 72 h / Heating View Scheme