2-氰基-5-甲氧基苯甲酸甲酯合成路线 （共 6 条）
反应条件
sodium carbonate; palladium diacetate in isobutyramide T=110°C; 36 h; Product distribution / selectivity;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/20306 A2, 2008 ;
Location in patent: Page/Page column 26-27 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=180°C; 0.0833333 h; Microwave irradiation;
参考文献
MERCK and CO., INC.
Patent: WO2007/56210 A2, 2007 ;
Location in patent: Page/Page column 47-48 ;
WO 2007/056210 A2
反应条件
N,N,N',N,-tetramethylethylenediamine; palladium diacetate; sodium carbonate; 1,2-bis-(diphenylphosphino)ethane; potassium iodide in N,N-dimethyl-formamide T=130°C; 22 h; Inert atmosphere;
参考文献
Zheng, Shuyan; Yu, Chunhui; Shen, Zhengwu
Organic Letters, 2012 , vol. 14, # 14 p. 3644 - 3647
反应条件
palladium diacetate; sodium carbonate in isobutyramide T=110°C; 36 h; Inert atmosphere;
参考文献
Powers, James J.; Favor, David A.; Rankin, Trent; Sharma, Rashmi; Pandit, Chetan; Jeganathan, Azhwarsamy; Maiti, Samarendra N.
Tetrahedron Letters, 2009 , vol. 50, # 12 p. 1267 - 1269
反应条件
1: 2-Bromo-5-methoxy benzoic acid methyl ester; copper (I) cyanide in N,N-dimethyl-formamide T=140°C; 0.5 h; 2: potassium cyanide in water T=50°C; 1 h; Product distribution / selectivity;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/20306 A2, 2008 ;
Location in patent: Page/Page column 26 ;
反应条件
hydrogen; nickel in methanol T=85°C; P=2585.81 Torr;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/20306 A2, 2008 ;
Location in patent: Page/Page column 26; 27-28 ;
