2-氰甲基苯甲酸甲酯合成路线

参考文献

GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
Location in patent: Page/Page column 113-114 ;
WO 2012/031004 A1

653-92-92-溴-4-氟苯甲酸甲酯+

544-92-3氰化亚铜

127510-96-72-氰甲基苯甲酸甲酯

参考文献

ASTRAZENECA AB
Patent: WO2005/58826 A1, 2005 ;
Location in patent: Page/Page column 100 ;
WO 2005/058826 A1

872-50-4N-甲基吡咯烷酮+

84194-36-52-氯-4-氟苯甲醛

127510-96-72-氰甲基苯甲酸甲酯

参考文献

GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy, B.
Patent: WO2012/30990 A1, 2012 ;
Location in patent: Page/Page column 70 ;
WO 2012/030990 A1

544-92-3氰化亚铜+

85953-29-32-氯-4-氟苯甲酸甲酯

127510-96-72-氰甲基苯甲酸甲酯

参考文献

Wrobel, Jay; Dietrich, Arlene; Woolson, Shiela A.; Millen, Jane; McCaleb, Michael; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4613 - 4627

127510-96-72-氰甲基苯甲酸甲酯

1260666-80-55-氟异吲哚啉-1-酮

参考文献

GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
Location in patent: Page/Page column 114 ;
WO 2012/031004 A1