4-(吗啉-4-羰基)溴苯合成路线 （共 12 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane; N,N-dimethyl-formamide T=20°C; 20 h;
参考文献
Takemiya, Akihiro; Hartwig, John F.
Journal of the American Chemical Society, 2006 , vol. 128, # 46 p. 14800 - 14801
反应条件
tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide in trichloroethane, 1,1,2-; water T=90°C; 12 h;
参考文献
Li, Huamin; Xie, Jin; Xue, Qicai; Cheng, Yixiang; Zhu, Chengjian
Tetrahedron Letters, 2012 , vol. 53, # 48 p. 6479 - 6482,4
反应条件
in dichloromethane Inert atmosphere;
参考文献
MERCK SERONO S.A.; CROSIGNANI, Stefano; JORAND-LEBRUN, Catherine; CLEVA, Christophe; PRETRE, Adeline
Patent: WO2010/92043 A1, 2010 ;
Location in patent: Page/Page column 133 ;
反应条件
potassium carbonate in toluene T=105°C; P=3000.3 Torr; 12 h;
参考文献
Dang, Tuan T.; Zhu, Yinghuai; Ngiam, Joyce S. Y.; Ghosh, Subhash C.; Chen, Anqi; Seayad, Abdul M.
ACS Catalysis, 2013 , vol. 3, # 6 p. 1406 - 1410
反应条件
1: morpholine With C12H30NaO6(1+)*C56H84O4Sm(1-) in tetrahydrofuran 0.5 h; Inert atmosphere; 2: 4-bromo-benzaldehyde in tetrahydrofuran T=25°C; 3 h; Inert atmosphere;
参考文献
Li, Junmei; Xu, Fan; Zhang, Yong; Shen, Qi
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2575 - 2577
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 24 h; Reflux;
参考文献
Rieke, Reuben D.; Kim, Seung-Hoi
Tetrahedron Letters, 2012 , vol. 53, # 27 p. 3478 - 3481
反应条件
dichlorophenyl phosphine oxide in acetonitrile T=-4°C; 3 h;
参考文献
Kim, Yong Hae; Lim, Sang Chul; Chang, Hae Sung
Journal of the Chemical Society, Chemical Communications, 1990 , # 1 p. 36 - 37
反应条件
1: morpholine With Sm(III) chloride; lithium hexamethyldisilazane in tetrahydrofuran T=20°C; 2: 4-Bromo-benzoic acid methyl ester in tetrahydrofuran T=0°C;
参考文献
Campbell, James B.; Sparks, Richard B.; Dedinas, Robert F.
Synlett, 2011 , # 3 art. no. S08010ST, p. 357 - 360
反应条件
in tetrahydrofuran; hexane T=0°C; 0.166667 h; Inert atmosphere;
参考文献
Park, Jae Kyo; Shin, Won Kyu; An, Duk Keun
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 5 p. 1592 - 1594
反应条件
1: p-bromophenyl bromide With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: 4-acetylmorpholine in tetrahydrofuran T=-78°C;
参考文献
Caron, Stephane; Do, Nga M.
Synlett, 2004 , # 8 p. 1440 - 1442
