1: 1N HCl / methanol / 1 h / Ambient temperature 2: BF3*Et2O / CH2Cl2 / 0.75 h 3: 90 percent / H2 / Raney Ni / ethyl acetate; methanol / 4 h / Ambient temperature 4: LDA / 0.08 h / -78 °C 5: 1) TFAA, DMSO 2) K-selectride / 1) 16h, 0 deg C; 2) Et2O, 0.5h 6: 1) imidazole 2) Jones reagent / 1) DMF View Scheme

Multi-step reaction with 5 steps 1: 1N HCl / methanol / 1 h / Ambient temperature2: BF3*Et2O / CH2Cl2 / 0.75 h3: 90 percent / H2 / Raney Ni / ethyl acetate; methanol / 4 h / Ambient temperature4: LDA / 0.08 h / -78 °C5: 1) TFAA, DMSO 2) K-selectride / 1) 16h, 0 deg C; 2) Et2O, 0.5h