甲基(1R,2S,3S,5S)-3-(4-氟苯基)-8-丙-2-烯基-8-氮杂双环[3.2.1]辛烷-2-羧酸酯合成路线 （共 4 条）
反应条件
potassium iodide in ethanol 16 h; Ambient temperature;
参考文献
Milius, Richard A.; Saha, Jayanta K.; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1728 - 1731
反应条件
1: 50percent aq. CH3COOH, Zn / 16 h / Ambient temperature 2: 47 percent / KI / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Milius, Richard A.; Saha, Jayanta K.; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1728 - 1731
反应条件
1: toluene / 1 h / 120 °C 2: 50percent aq. CH3COOH, Zn / 16 h / Ambient temperature 3: 47 percent / KI / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Milius, Richard A.; Saha, Jayanta K.; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1728 - 1731
反应条件
1: 11 percent / diethyl ether / 1 h / -20 °C 2: toluene / 1 h / 120 °C 3: 50percent aq. CH3COOH, Zn / 16 h / Ambient temperature 4: 47 percent / KI / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Milius, Richard A.; Saha, Jayanta K.; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1728 - 1731
