(S)-3-苄氧基-2-羟基丙酸甲酯合成路线 （共 12 条）
反应条件
hydrogenchloride in methanol T=20°C; 18 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 14 p. 1689 - 1697
反应条件
sulfuric acid 16 h; Reflux;
参考文献
WO2012/142671 A1, ;
Page/Page column 35; 36 ;
反应条件
hydrogenchloride; trimethyl orthoformate in methanol T=20°C; 19.5 h; Large scale;
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532
参考文献
Tetrahedron Letters, , vol. 30, # 40 p. 5505 - 5506
反应条件
1: NaNO2, H2SO4 / 16 h / Ambient temperature 2: 70 percent / H+ View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 40 p. 5505 - 5506
反应条件
1.1: trifluoroacetic acid / 0.75 h / 20 °C 1.2: 20 h / 5 - 20 °C / pH 4 2.1: sulfuric acid / 16 h / Reflux View Scheme
反应条件
1: N-tert-butoxycarbonyl-O-benzyl-L-serine With trifluoroacetic acid T=20°C; 1 h; 2: With water; sodium nitrite in acetone T=5 - 20°C; pH=4; 16 h; 3: trimethyl orthoformate With sulfuric acid in methanol 16 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 353 - 359
反应条件
1: 83 percent / Ph3P, DEAD 2: 90 percent / LiAlH4 3: pyridine View Scheme
参考文献
Witt, P. De; Misiti, D.; Zappia, G.
Tetrahedron Letters, 1989 , vol. 30, # 40 p. 5505 - 5506
反应条件
1: LiAlH4 / tetrahydrofuran 2: pyridine 3: sodium methoxide View Scheme
参考文献
Witt, P. De; Misiti, D.; Zappia, G.
Tetrahedron Letters, 1989 , vol. 30, # 40 p. 5505 - 5506
反应条件
1: LiAlH4 / tetrahydrofuran 2: pyridine View Scheme
参考文献
Witt, P. De; Misiti, D.; Zappia, G.
Tetrahedron Letters, 1989 , vol. 30, # 40 p. 5505 - 5506
