6-氨甲基-6,11-二氢-5H-二苯并[b,e]氮杂卓富马酸盐合成路线 (共 3 条)
反应条件
1: N-lt;(11H-dibenzlt;b,egt;azepin-6-yl)methylgt;phthalimide With sodium tetrahydroborate in methanol; water; isopropyl alcohol; toluene T=20 - 30°C; 24.5 h; 2: With hydrogenchloride in water; isopropyl alcohol T=20 - 80°C; 1.5 h; 3: (2E)-but-2-enedioic acid With sodium hydroxide Product distribution / selectivity; more than 3 stages;
参考文献
Konica Minolta Chemical Co., Ltd.
Patent: EP1496051 A1, 2005 ;
Location in patent: Page 3 ;
反应条件
in methanol T=35 - 40°C; 1.5 - 1.66667 h;
参考文献
WO2009/63504 A2, ;
Page/Page column 24 ;
反应条件
sodium hydroxide in water T=25 - 30°C; 0.5 h;
参考文献
USV LIMITED
Patent: WO2009/63504 A2, 2009 ;
Location in patent: Page/Page column 24 ;