3,4-双(二氟甲氧基)苯甲醛合成路线 （共 11 条）
反应条件
1: With potassium carbonate in water; N,N-dimethyl-formamide T=100°C; 2 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide 3: With sodium hydroxide in water; N,N-dimethyl-formamide pH=> 9;
参考文献
WO2006/76246 A2, ;
Page/Page column 220 ;
WO 2006/076246 A2
反应条件
potassium carbonate in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
US5710170 A1, ;
US 5710170 A
反应条件
caesium carbonate in N,N-dimethyl-formamide T=65°C; 3 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 24 p. 7673 - 7688
反应条件
1: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in DMF (N,N-dimethyl-formamide); water 0.05 h; 2: With hydrogenchloride in DMF (N,N-dimethyl-formamide); water
参考文献
WO2005/21515 A2, ;
Page/Page column 64-65 ;
WO 2005/021515 A2
反应条件
potassium hydroxide in isopropyl alcohol 70 h;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 25, # 11.2 p. 2134 - 2138
Zhurnal Organicheskoi Khimii, , vol. 25, # 11 p. 2367 - 2372
反应条件
caesium carbonate in N,N-dimethyl-formamide
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 11 p. 1457 - 1461
反应条件
caesium carbonate in N,N-dimethyl-formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 16 p. 2149 - 2152
反应条件
sodium hydroxide; sodium borohydride in ethanol
参考文献
SmithKline Beecham Corporation
Patent: US5605923 A1, 1997 ;
US 5605923 A
反应条件
1: 4 h / 160 - 180 °C 2: conc. HCl / methanol / 48 h / 20 °C View Scheme
参考文献
MERCK and CO., INC.
Patent: WO2009/20642 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/020642 A1
反应条件
1: tetrahydrofuran / 2 h / 0 - 20 °C
2: pyridinium chlorochromate / dichloromethane / 16 h / 20 °C / |Molecular sieve
View Scheme
参考文献
Williams, Spencer J.; Zammit, Steven C.; Cox, Alison J.; Shackleford, David M.; Morizzi, Julia; Zhang, Yuan; Powell, Andrew K.; Gilbert, Richard E.; Krum, Henry; Kelly, Darren J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6868 - 6873
