6-(Fmoc-氨基)-1-己醇合成路线 （共 7 条）
反应条件
pyridine in methanol
T=23°C; 16 h;
参考文献
Matsumori, Nobuaki; Yamaji, Nahoko; Matsuoka, Shigeru; Oishi, Tohru; Murata, Michio
Journal of the American Chemical Society, 2002 , vol. 124, # 16 p. 4180 - 4181
反应条件
sodium hydrogencarbonate in 1,4-dioxane
T=0 - 20°C;
参考文献
Nasopoulou, Magdalini; Georgiadis, Dimitris; Matziari, Magdalini; Dive, Vincent; Yiotakis, Athanasios
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7222 - 7228
反应条件
trichloromonobromomethane; Ir[(dF(CF3)ppy)2(dtbbpy)]PF6; water in acetonitrile
12 h; Inert atmosphereIrradiation; chemoselective reaction;
参考文献
Tucker, Joseph W.; Narayanam, Jagan M. R.; Shah, Pinkey S.; Stephenson, Corey R. J.
Chemical Communications, 2011 , vol. 47, # 17 p. 5040 - 5042
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=-78 - 0°C; 0.666667 h;
2: With sodium tetrahydroborate in tetrahydrofuran; methanol
T=-78 - 20°C; Further stages.;
参考文献
Quintanar-Audelo, Martina; Fernandez-Carvajal, Asia; Van Den Nest, Wim; Carreno, Cristina; Ferrer-Montiel, Antonio; Albericio, Fernando
Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 6133 - 6143
反应条件
1: sodium carbonate / tetrahydrofuran; water / 20 °C / Inert atmosphere
2: Ir[(dF(CF3)ppy)2(dtbbpy)]PF6; trichloromonobromomethane; water / acetonitrile / 12 h / Inert atmosphere; Irradiation
View Scheme
参考文献
Tucker, Joseph W.; Narayanam, Jagan M. R.; Shah, Pinkey S.; Stephenson, Corey R. J.
Chemical Communications, 2011 , vol. 47, # 17 p. 5040 - 5042
反应条件
1: pyridine / 18 h / 37 °C
2: pyridine / 18 h / 5 °C
3: NaN3 / dimethylformamide / 5 h / 90 °C
4: aq. ammonia; 2-mercaptoethanol / dimethylformamide / 18 h / 20 °C
5: pyridine / 18 h / 20 °C
6: acetic acid / H2O / 18 h / 20 °C
View Scheme
参考文献
Khandazhinskaya; Kukhanova; Jasko
Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 4 p. 352 - 356
反应条件
1: pyridine / 18 h / 5 °C
2: NaN3 / dimethylformamide / 5 h / 90 °C
3: aq. ammonia; 2-mercaptoethanol / dimethylformamide / 18 h / 20 °C
4: pyridine / 18 h / 20 °C
5: acetic acid / H2O / 18 h / 20 °C
View Scheme
参考文献
Khandazhinskaya; Kukhanova; Jasko
Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 4 p. 352 - 356
