1: aq. HCl / tetrahydrofuran / 48 h / 5 °C 2: 97 percent / H2, Pd(OH)2/C / methanol 3: 1) Et3N, 2) KOH / 1) THF, 0-5 deg C, 30 min; room temperature, 3.5 h, 2) THF, MeOH, 0-5 deg C 15 min; room temperature, 75 min View Scheme

1: aq. HCl / tetrahydrofuran / 48 h / 5 °C 2: 97 percent / H2, Pd(OH)2/C / methanol 3: 1) Et3N, 2) KOH / 1) THF, 0-5 deg C, 30 min; room temperature, 3.5 h, 2) THF, MeOH, 0-5 deg C 15 min; room temperature, 75 min View Scheme