4-氧代四氢-2H-吡喃-3-羧酸甲酯合成路线 （共 4 条）
反应条件
sodium hydride in tetrahydrofuran; hexane T=45°C;
参考文献
ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David
Patent: WO2014/15291 A1, 2014 ;
Location in patent: Page/Page column 183 ;
反应条件
1: tetrahydro-pyran-4-one With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.333333 h; 2: methoxycarbonyl cyanide in tetrahydrofuran 3: With ammonium chloride in tetrahydrofuran
参考文献
Sengupta, Prabal; Puri, Chetan S.; Chokshi, Hemant A.; Sheth, Chetana K.; Midha, Ajay S.; Chitturi, Trinadha Rao; Thennati, Rajamannar; Murumkar, Prashant R.; Yadav, Mange Ram
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5549 - 5555
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-78°C; 0.25 h; 2: With water in tetrahydrofuran; hexanes
参考文献
SYNDAX PHARMACEUTICALS, INC.
Patent: WO2009/49018 A1, 2009 ;
Location in patent: Page/Page column 103 ;
WO 2009/049018 A1
反应条件
1: tetrahydro-pyran-4-one With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 1.5 h; 2: methoxycarbonyl cyanide in tetrahydrofuran T=-78°C; 0.166667 h; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
Wyeth
Patent: US2006/211730 A1, 2006 ;
Location in patent: Page/Page column 37 ;
US 20060211730 A1
