2-甲氧基-5-甲基苯硼酸合成路线 （共 6 条）
反应条件
1: 2-bromo-1-methoxy-4-methyl-benzene With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C; 4 h; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Erickson-Miller, Connie J; Eppley, Daniel F.; Jenkins, Julian; Luengo, Juan I.; Liu, Nannan; Price, Alan T.; Shaw, Anthony N.; Visonneau, Sophie; Wiggall, Kenneth
Patent: US2004/19190 A1, 2004 ;
Location in patent: Page 24 ;
反应条件
1: 4-methoxy-toluene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether T=20°C; 12 h; Inert atmosphere; 2: boric acid trimethyl ester in diethyl ether T=20°C; 3 h; Inert atmosphere;
参考文献
Akine, Shigehisa; Nagumo, Hiroki; Nabeshima, Tatsuya
Dalton Transactions, 2013 , vol. 42, # 45 p. 15974 - 15986
反应条件
1.1: Mg; I2 / diethyl ether / 20 °C 1.2: diethyl ether / -80 - 20 °C 2.1: aq. HCl / 20 °C View Scheme
参考文献
Macromolecules, , vol. 37, # 22 p. 8201 - 8203
反应条件
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 24 h / 80 °C 2: tert-butyl alcohol; sodium chlorite; sodium dihydrogenphosphate / tetrahydrofuran; water / 3 h / 20 °C View Scheme
参考文献
Demuner, Antonio Jacinto; Barbosa, Luiz Claudio Almeida; Miranda, Ana Cristina Mendes; Geraldo, Guilherme Carvalho; Da Silva, Cleiton Moreira; Giberti, Samuele; Bertazzini, Michele; Forlani, Giuseppe
Journal of Natural Products, 2013 , vol. 76, # 12 p. 2234 - 2245
反应条件
1: With boron tribromide in dichloromethane
T=-78 - 20°C; Inert atmosphere;
2: With methanol in dichloromethane
T=-78°C; Inert atmosphere;
参考文献
Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758
反应条件
1: Pd catalyst
2: BBr3
View Scheme
参考文献
Hayashi, Naoto; Yamaguchi, Kumiko; Matsumoto, Kiyoshi
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2002 , vol. 390, p. 5 - 10
