5-醛基-2-甲氧基苯硼酸合成路线 （共 5 条）
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-70°C; 4 h; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane T=-70 - 20°C; Further stages;
参考文献
Beilstein Journal of Organic Chemistry, , vol. 5, art. no. A71
反应条件
1: 97 percent / toluene-4-sulfonic acid / toluene / 24 h / Heating 2: 1.) 2.5 M nBuLi; 2.) tributyl borate; 3.) 2M HCl / 1.) diethyl ether, hexane, -70 deg C, 4 h; 2.) 12 h, 20 deg C; 3.) water View Scheme
参考文献
European Journal of Organic Chemistry, , # 5 p. 877 - 888
反应条件
1.1: bromine; AlCl3, aluminium chloride / 1,2-dichloro-ethane 2.1: orthoformic acid triethyl ester; tetra-n-butylammonium tribromide 3.1: n-butyllithium / -70 °C 3.2: |Acidic conditions View Scheme
参考文献
Indian Journal of Heterocyclic Chemistry, , vol. 21, # 3 p. 281 - 288
反应条件
1: With n-butyllithium T=-70°C; 2: With water Acidic conditions;
参考文献
Indian Journal of Heterocyclic Chemistry, , vol. 21, # 3 p. 281 - 288
反应条件
tetrakis(triphenylphosphine) palladium(0); caesium carbonate in ethanol; toluene T=180°C; Suzuki coupling; 0.333333 h; Microwave irradiation;
参考文献
Brunton, Shirley A.; Stibbard, John H.A.; Rubin, Lee L.; Guicherit, Oivin M.; Kruse, Lawrence I.; Price, Stephen; di Lucrezia, Raffaella; MacKinnon, Colin H.; Avery, Alaric; Park, Yvonne; Buxton, Danielle; Boyd, Edward A
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4308 - 4311
