(5-甲氧基吡啶-2-基)甲醇合成路线 （共 8 条）
反应条件
diisobutylaluminium hydride in toluene T=-78 - 0°C; Inert atmosphere;
参考文献
Koay, Natalie; Tonelli, Devin L.; Truong, Vouy Linh
Tetrahedron Letters, 2011 , vol. 52, # 1 p. 122 - 124
反应条件
sodium tetrahydroborate in methanol T=0°C; 0.166667 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27746 A1, 2009 ;
Location in patent: Page/Page column 111 ;
WO 2009/027746 A1
反应条件
in methanol; ethyl acetate
参考文献
Warner-Lambert Company
Patent: US6194437 B1, 2001 ;
US 6194437 B1
反应条件
trifluoroacetic anhydride in dichloromethane T=0 - 20°C;
参考文献
Adamczyk, Maciej; Reddy, Rajarathnam E.
Tetrahedron Asymmetry, 2001 , vol. 12, # 7 p. 1047 - 1054
反应条件
1: 75 percent / sodium hydride / dimethylformamide / 4 h / 20 °C 2: 35 percent / H2O2; acetic acid / H2O / 5 h / 100 °C 3: CH2Cl2 / 0 - 20 °C 4: 573 mg / CH2Cl2; methanol / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 24 p. 6763 - 6770
反应条件
1: 35 percent / H2O2; acetic acid / H2O / 5 h / 100 °C 2: CH2Cl2 / 0 - 20 °C 3: 573 mg / CH2Cl2; methanol / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 24 p. 6763 - 6770
反应条件
phosphorus tribromide in dichloromethane T=20°C; Cooling;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; OOST, Thorsten; LOTZ, Ralf; STENKAMP, Dirk
Patent: WO2013/131935 A1, 2013 ;
Location in patent: Page/Page column 52 ;
反应条件
thionyl chloride in dichloromethane T=25°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
