5beta-孕甾烷-3,20-二酮合成路线 （共 54 条）
反应条件
1: CrO3; acetic acid / Behandeln des Reaktionsprodukts in Aether mit wss. NaOH 2: ethanol; palladium/barium sulfate / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 62, p. 516
反应条件
1: ueber Pseudodiosgenon 2: diethyl ether; palladium/barium sulfate / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 62, p. 2537,2539
反应条件
1: 94 percent / AcOCl / 25 h / 55 °C 3: 1) N,N-carbonyldiimidazole / 1) THF, 25 degC, 5 h; 2) THF, irradiation 4: 1) O3; 2) Zn, HCOOH / 1) CH2Cl2, -78 degC, 15 min View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 17 p. 1765 - 1768
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; C9H18N2*C10H16O4S in acetonitrile 72 h; Reflux; Overall yield = 78 percent; stereoselective reaction;
参考文献
RSC Advances, , vol. 3, # 32 p. 13497 - 13506
反应条件
acetic acid; zinc T=100°C;
反应条件
1: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 4 h / Reflux; Inert atmosphere 2: hydrogenchloride; water / 0.25 h View Scheme
参考文献
Steroids, , vol. 77, # 3 p. 282 - 287
反应条件
1.1: PCC-alumina / benzene / 36 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux 3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C 3.2: 20 °C 4.1: 2 h 5.1: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 4 h / Reflux; Inert atmosphere 6.1: hydrogenchloride; water / 0.25 h View Scheme
参考文献
Steroids, , vol. 77, # 3 p. 282 - 287
反应条件
1.1: pyridine; Lindlar catalyst; hydrogen / 8 h 2.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / benzene / 20 °C 3.1: PCC-alumina / benzene / 36 h / 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux 5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C 5.2: 20 °C 6.1: 2 h 7.1: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 4 h / Reflux; Inert atmosphere 8.1: hydrogenchloride; water / 0.25 h View Scheme
参考文献
Steroids, , vol. 77, # 3 p. 282 - 287
反应条件
1.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / benzene / 20 °C 2.1: PCC-alumina / benzene / 36 h / 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux 4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C 4.2: 20 °C 5.1: 2 h 6.1: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 4 h / Reflux; Inert atmosphere 7.1: hydrogenchloride; water / 0.25 h View Scheme
参考文献
Steroids, , vol. 77, # 3 p. 282 - 287
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C 1.2: 20 °C 2.1: 2 h 3.1: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 4 h / Reflux; Inert atmosphere 4.1: hydrogenchloride; water / 0.25 h View Scheme
参考文献
Steroids, , vol. 77, # 3 p. 282 - 287
