5-甲基-3-(硝基甲基)己酸乙酯合成路线 （共 9 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene T=0 - 30°C; 2.5 h;
参考文献
Generics [UK] Limited; Mylan India Private Limted
Patent: US2010/324139 A1, 2010 ;
Location in patent: Page/Page column 11; 12; 13 ;
反应条件
1: propanedioic acid monoethyl ester; isovaleraldehyde With 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide T=15 - 20°C; 24 h; 2: nitromethane With N,N,N',N'-tetramethylguanidine in toluene T=25°C; 18 h;
参考文献
EP2110372 A1, ;
Page/Page column 10-11 ;
反应条件
N,N,N',N'-tetramethylguanidine 48 h; Ambient temperature;
参考文献
Andruszkiewicz; Silverman
Synthesis, 1989 , # 12 p. 953 - 955
反应条件
1: piperidine; pyridine / 0 - 80 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C / Inert atmosphere View Scheme
反应条件
1.1: potassium hydroxide; water / 0 - 20 °C 1.2: Raney nickel / 20 °C / 2585.81 Torr 1.3: 0 - 3 °C / pH 7 2.1: (S)-α-hydroxybenzeneacetic acid / isopropyl alcohol; water / Resolution of racemate View Scheme
反应条件
methanol; sodium tetrahydroborate; NiII chloride hexahydrate T=40 - 45°C; 12 h; Reagent/catalystTemperatureTime;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; HE, Fang; ZHANG, Yaobin; KOU, Jingping
Patent: WO2014/5494 A1, 2014 ;
Location in patent: Paragraph 0028 ;
反应条件
1: With water; potassium hydroxide T=0 - 20°C; 2: With hydrogen; Raney nickel in methanol; ethanol T=20°C; P=2585.81 Torr; 3: With acetic acid T=0 - 3°C; pH=7; Product distribution / selectivity;
参考文献
HELVETICA INDUSTRIES (P) LIMITED; PRADHAN, B., S.
Patent: WO2011/16052 A2, 2011 ;
Location in patent: Page/Page column 13; 14 ;
反应条件
1: With water; potassium hydroxide T=0 - 20°C; 2: With hydrogen; Raney nickel in methanol; ethanol T=20°C; P=2585.81 Torr; 3: With acetic acid T=0 - 3°C; pH=7; Product distribution / selectivity;
参考文献
HELVETICA INDUSTRIES (P) LIMITED; PRADHAN, B., S.
Patent: WO2011/16052 A2, 2011 ;
Location in patent: Page/Page column 13; 14 ;
反应条件
1: With water; potassium hydroxide
T=0 - 20°C;
2: With hydrogen; Raney nickel in methanol; ethanol
T=20°C; P=2585.81 Torr;
3: With acetic acid
T=0 - 3°C; pH=7; Product distribution / selectivity;
参考文献
HELVETICA INDUSTRIES (P) LIMITED; PRADHAN, B., S.
Patent: WO2011/16052 A2, 2011 ;
Location in patent: Page/Page column 13; 14 ;
