3-氨甲基-5-甲基己酸合成路线 （共 41 条）
反应条件
hydrogen; 5-palladium/activated carbon in methanol T=25 - 30°C; 6 - 8 h;
参考文献
GENERICS [UK] LIMITED; MYLAN DEVELOPMENT CENTRE PRIVATE LIMITED
Patent: WO2009/147434 A1, 2009 ;
Location in patent: Page/Page column 21; 29-30 ;
反应条件
1: With water; potassium hydroxide T=0 - 20°C; 2: With hydrogen; Raney nickel in methanol; ethanol T=20°C; P=2585.81 Torr; 3: With acetic acid T=0 - 3°C; pH=7; Product distribution / selectivity;
参考文献
HELVETICA INDUSTRIES (P) LIMITED; PRADHAN, B., S.
Patent: WO2011/16052 A2, 2011 ;
Location in patent: Page/Page column 13; 14 ;
反应条件
1: With sodium hydroxide; water; bromine T=5 - 60°C; Hofmann Rearrangement; 0.5 h; 2: With sulfuric acid in 2-methyl-propan-1-ol; water 3: With tributyl-amine in 2-methyl-propan-1-ol T=2 - 10°C; 1.5 - 2 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/121557 A1, 2006 ;
Location in patent: Page/Page column 13-14; 17 ;
反应条件
hydrogen; acetic acid; 20 palladium hydroxide on carbon in methanol P=29422.9 Torr; 24 h; autoclave;
参考文献
WO2011/86565 A1, ;
Page/Page column 40-41 ;
反应条件
hydrogen; trifluoroacetic acid; 20 palladium hydroxide on carbon in methanol P=29422.9 Torr; 24 h; autoclave;
参考文献
WO2011/86565 A1, ;
Page/Page column 41 ;
反应条件
hydrogen; Pd(OH)2 (10 on C) in methanol P=3677.86 Torr; autoclave;
参考文献
WO2011/86565 A1, ;
Page/Page column 42 ;
反应条件
acetic acid in ethanol; water T=0 - 75°C; 4 h;
参考文献
US2006/270871 A1, ;
Page/Page column 3 ;
反应条件
1: With potassium hydroxide in water T=0°C; 30 h; 2: With potassium hypobromide in water T=0 - 80°C; 1.16667 h; 3: With acetic acid in water T=80 - 90°C; 0.5 h;
参考文献
Dr. Braja Sundar Pradhan
Patent: WO2012/93411 A2, 2012 ;
Location in patent: Page/Page column 30 ;
反应条件
hydrogen in methanol P=29422.9 Torr; autoclave;
参考文献
WO2011/86565 A1, ;
Page/Page column 39-40 ;
反应条件
1: With sodium hydroxide; bromine in water T=5 - 35°C; 2: With sulfuric acid in 2-methyl-propan-1-ol; water T=35°C; pH=0.5 - 3; 3: With tributyl-amine T=0 - 20°C; 2 - 8 h;
参考文献
WO2009/46309 A2, ;
Page/Page column 18 ;
