(2S,3s)-3-(苄氧基羰基氨基)-1-氯-2-羟基-4-苯基丁烷合成路线 （共 13 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran; methanol T=-2 - 20°C; 1.66667 - 3.66667 h; 2: With potassium hydrogensulfate in water; ethyl acetate 3: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
US6388132 B1, ;
Page column 44-45,51 ;
反应条件
aluminum isopropoxide; isopropyl alcohol in toluene T=50°C; Meerwein-Ponndorf-Verley reduction; 18 h;
参考文献
Journal of Organic Chemistry, , vol. 71, # 2 p. 840 - 843
反应条件
1: 2.) HCl / 1.) Et2O 2: NaBH4 / ethanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 6 p. 1145 - 1155
反应条件
1: NMM / tetrahydrofuran 2: 2.) HCl / 1.) Et2O 3: NaBH4 / ethanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 6 p. 1145 - 1155
反应条件
1: HCl / dioxane; diethyl ether / 1 h / 0 °C 2: NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1758 - 1768
反应条件
1.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 1.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 2.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C 3.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C 4.1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070
反应条件
1.1: 91 percent / aq. Na2CO3 / toluene / 1 h / 5 - 10 °C 2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 2.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 3.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C 4.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C 5.1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070
反应条件
1.1: 91 percent / aq. Na2CO3 / toluene / 1 h / 5 - 10 °C 2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 2.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 3.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C 4.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C 5.1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070
反应条件
1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C 2: 20.1 g / aq. HCOOH / 0.33 h / 80 °C 3: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070
反应条件
1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C 2: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070
