(2S,3S)-1,2-环氧-3-苄氧羰基氨基-4-苯基丁烷合成路线 （共 18 条）
反应条件
potassium hydroxide in ethanol T=20°C; 1 h;
参考文献
Yin, Jingjun; Huffman, Mark A.; Conrad, Karen M.; Armstrong III, Joseph D.
Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 840 - 843
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran; methanol T=0°C; 2: With triethylamine in dichloromethane T=0°C; 1 h; 3: With p-toluenesulfonyl chloride in dichloromethane T=0°C; 1 h;
参考文献
The Scripps Research Institute
Patent: US6900238 B1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
1: 94 percent / aluminum isopropoxide; isopropyl alcohol / toluene / 18 h / 50 °C 2: 99 percent / potassium hydroxide / ethanol / 1 h / 20 °C View Scheme
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
1: 2.) HCl / 1.) Et2O 2: NaBH4 / ethanol 3: 96 percent / NaOMe / methanol View Scheme
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
sodium chloride; potassium carbonate; citric acid in methanol; hexane; water
参考文献
Nippon Kayaku Kabushiki Kaisha
Patent: US5488118 A1, 1996 ;
反应条件
sodium chloride; potassium carbonate; citric acid in methanol; water
参考文献
Nippon Kayaku Kabushiki Kaisha
Patent: US5488118 A1, 1996 ;
反应条件
potassium carbonate in methanol
参考文献
Ajinomoto Co., Inc.
Patent: US5767316 A1, 1998 ;
反应条件
1: 82 percent / HBr 2: 45 percent / NaBH4 View Scheme
参考文献
Albeck, Amnon; Persky, Rachel
Tetrahedron, 1994 , vol. 50, # 21 p. 6333 - 6346
反应条件
1: NMM / tetrahydrofuran 2: 2.) HCl / 1.) Et2O 3: NaBH4 / ethanol 4: 96 percent / NaOMe / methanol View Scheme
参考文献
He, Meizi; Zhang, Hang; Yao, Xiaojian; Eckart, Michael; Zuo, Elizabeth; Yang, Ming
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 174 - 180
反应条件
potassium carbonate in methanol T=20°C; 3 h;
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2061 - 2070
