(2S,3S)-1,2-环氧-3-苄氧羰基氨基-4-苯基丁烷合成路线 （共 18 条）
反应条件
1: Ti(iPrO)2(N3)2 / benzene / 75 °C 2: 66 percent / H2 / 10 percent Pd/C / methanol / 760 Torr 3: 74 percent / NaHCO3 / H2O / 50 °C 4: 69 percent / PPh3; DEAD / CHCl3 / Heating View Scheme
参考文献
Catasus, Monica; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9309 - 9312
反应条件
1: 66 percent / H2 / 10 percent Pd/C / methanol / 760 Torr 2: 74 percent / NaHCO3 / H2O / 50 °C 3: 69 percent / PPh3; DEAD / CHCl3 / Heating View Scheme
参考文献
Catasus, Monica; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9309 - 9312
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=0°C; Yield given;
参考文献
Sham, Hing L.; Betebenner, David A.; Zhao, Chen; Wideburg, Norman E.; Saldivar, Ayda; et al.
Journal of the Chemical Society, Chemical Communications, 1993 , # 13 p. 1052 - 1053
反应条件
sodium tetrahydroborate
参考文献
Heinsoo; Raidaru; Linask; Jarv; Zetterstrom; Langel
Tetrahedron Asymmetry, 1995 , vol. 6, # 9 p. 2245 - 2247
反应条件
1: 74 percent / NaHCO3 / H2O / 50 °C 2: 69 percent / PPh3; DEAD / CHCl3 / Heating View Scheme
参考文献
Catasus, Monica; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9309 - 9312
反应条件
sodium tetrahydroborate in ethanol 4 h; Yield given. Yields of byproduct given;
参考文献
Albeck, Amnon; Persky, Rachel
Tetrahedron, 1994 , vol. 50, # 21 p. 6333 - 6346
反应条件
1.1: 60.3 percent / propan-2-ol / 5 h / Heating 2.1: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C 3.1: HOBt; BOP; DIPEA / dimethylformamide / 0.17 h / 0 °C 3.2: Et3N / dimethylformamide / 0 - 20 °C 4.1: HCl / dioxane / 0 - 20 °C 5.1: DIPEA / dimethylformamide / 0 - 20 °C View Scheme
参考文献
Tamamura, Hirokazu; Koh, Yasuhiro; Ueda, Satoshi; Sasaki, Yoshikazu; Yamasaki, Tomonori; Aoki, Manabu; Maeda, Kenji; Watai, Yoriko; Arikuni, Hisashi; Otaka, Akira; Mitsuya, Hiroaki; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2003 , vol. 46, # 9 p. 1764 - 1768
反应条件
1: 60.3 percent / propan-2-ol / 5 h / Heating 2: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C View Scheme
参考文献
Tamamura, Hirokazu; Koh, Yasuhiro; Ueda, Satoshi; Sasaki, Yoshikazu; Yamasaki, Tomonori; Aoki, Manabu; Maeda, Kenji; Watai, Yoriko; Arikuni, Hisashi; Otaka, Akira; Mitsuya, Hiroaki; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2003 , vol. 46, # 9 p. 1764 - 1768
