吡咯并[3,4-c]吡唑-5(2H,4h,6h)-羧酸叔丁酯合成路线 （共 5 条）
反应条件
hydrazine hydrate in ethanol T=20°C; 5 h;
参考文献
GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; GOSSELIN, Francis; YUEN, Po-Wai; ZAK, Mark; ZHENG, Xiaozhang
Patent: WO2013/127267 A1, 2013 ;
Location in patent: Page/Page column 97; 98 ;
反应条件
N-ethyl-N,N-diisopropylamine in methanol; dichloromethane T=20°C;
参考文献
MERCK SHARP and DOHME CORP.; BIFTU, Tesfaye; KHAN, Tanweer, A.
Patent: WO2014/18355 A1, 2014 ;
Location in patent: Page/Page column 30 ;
反应条件
hydrazine in ethanol T=85°C; 4 h; Sealed tube; Product distribution / selectivity;
参考文献
MERCK SHARP and DOHME CORP.; HICKS, Jacqueline, D.; BIFTU, Tesfaye; CHEN, Ping; QIAN, Xiaoxia; WILKENING, Robert, R.
Patent: WO2011/146358 A1, 2011 ;
Location in patent: Page/Page column 61 ;
反应条件
1: 0.67 h / 105 °C 2: hydrazine / ethanol / 4 h / 85 °C / Sealed tube View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COX, Jason, M.; BIFTU, Tesfaye; CHU, Hong Dong; FENG, Danqing; WEBER, Ann, E.
Patent: WO2011/37793 A1, 2011 ;
反应条件
1: With hydrogenchloride; water in methanol 12 h; 2: With ammonium hydroxide; ammonia in methanol; water
参考文献
MERCK SHARP and DOHME CORP.; WILKENING, Robert, R.; APGAR, James, M.; BIFTU, Tesfaye; FENG, Danqing; QIAN, Xiaoxia; WEI, Lan
Patent: WO2011/103256 A1, 2011 ;
Location in patent: Page/Page column 57 ;
WO 2011/103256 A1
