4-溴-2-氟吡啶合成路线

参考文献

Journal of Organic Chemistry, , vol. 57, # 2 p. 565 - 573

参考文献

Marsais; Pineau; Nivolliers; Mallet; Turck; Godard; Queguiner
Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 565 - 573

128071-98-74-溴-2-氟吡啶

1173155-38-8

参考文献

Lu, Kai; Jiang, Yu; Chen, Bin; Eldemenky, Eman M.; Ma, Gil; Packiarajan, Mathivanan; Chandrasena, Gamini; White, Andrew D.; Jones, Kenneth A.; Li, Boshan; Hong, Sang-Phyo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5310 - 5314

128071-98-74-溴-2-氟吡啶+

67-63-0异丙醇

1142194-24-8

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SCHERING CORPORATION
Patent: WO2009/105500 A1, 2009 ;
Location in patent: Page/Page column 274 ;
WO 2009/105500 A1

4426-11-3环丁腈+

128071-98-74-溴-2-氟吡啶

1163707-59-21-(4-溴吡啶-2-基)环丁烷甲腈

参考文献

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128071-98-74-溴-2-氟吡啶+

57260-71-61-Boc-哌嗪

1197294-80-64-(4-溴吡啶-2-基)哌嗪-1-羧酸叔丁酯

参考文献

Almirall, S.A.; Vidal Juan, Bernat; Forns Berenguel, Maria Pilar; Castillo Mcquade, Marcos; Erra Sola, Montserrat; Mir Cepeda, Marta
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Location in patent: Paragraph 0176 ;

863409-08-95-(2-(甲氧基羰基)吡啶-4-基)-呋喃-2-羧酸

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BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/79791 A1, 2005 ;
Location in patent: Page/Page column 125 ;
WO 2005/079791 A1

128071-98-74-溴-2-氟吡啶+

100-51-6苯甲醇

960298-00-42-(苄氧基)-4-溴吡啶

参考文献

ASTRAZENECA AB; HOLENZ, Joerg; KARLSTROeM, Sofia; KIHLSTROeM, Jacob; KOLMODIN, Karin; LINDSTROeM, Johan; RAKOS, Laszlo; ROTTICCI, Didier; SWAHN, Britt-Marie; VON BERG, Stefan
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WO 2011/002409 A1