5-氯吡啶-2-甲酸乙酯合成路线 （共 10 条）
反应条件
1: With sulfuric acid T=80°C; 16 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 76 ;
WO 2009/135842 A1
反应条件
triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate in N,N-dimethyl-formamide T=50°C; P=760.051 Torr;
参考文献
EP1748048 A1, ;
Page/Page column 33 ;
反应条件
sodium iodide; triethylamine; triphenylphosphine; carbon monoxide; palladium diacetate in ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate T=120°C; Carboxylation; P=11250.9 Torr; 1 h;
参考文献
Bessard, Yves; Crettaz, Roger
Heterocycles, 1999 , vol. 51, # 11 p. 2589 - 2602
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate T=135°C; Carboxylation; P=11250.9 Torr; 1 h;
参考文献
Heterocycles, , vol. 51, # 11 p. 2589 - 2602
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 1.2: 0 - 20 °C 2.1: phosphorus tribromide / dichloromethane / 1 h / 20 °C View Scheme
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRADL, Stefan; LAIRD, Ellen; MORENO, David; REN, Li; WENGLOWSKY, Steven Mark
Patent: WO2011/25968 A1, 2011 ;
WO 2011/025968 A1
反应条件
diisobutylaluminium hydride in dichloromethane; toluene 0.333333 h;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14902 A2, 2004 ;
Location in patent: Page 42 ;
WO 2004/014902 A2
反应条件
1: With diisopropylaluminium hydride in tetrahydrofuran; toluene T=0°C; 2 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol; toluene T=0 - 20°C; 3 h; 3: With methanol; water; sodium sulfate in tetrahydrofuran; diethyl ether; toluene T=20°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1916239 A1, 2008 ;
Location in patent: Page/Page column 28 ;
EP 1916239 A1
反应条件
1: sodium azide / dimethyl sulfoxide / 120 °C 2: hydrogenchloride / dimethyl sulfoxide / 2 h / 120 °C View Scheme
参考文献
Kandalkar, Sachin R.; Kaduskar, Rahul D.; Ramaiah, Parimi Atchuta; Barawkar, Dinesh A.; Bhuniya, Debnath; Deshpande, Anil M.
Tetrahedron Letters, 2013 , vol. 54, # 5 p. 414 - 418
反应条件
1.1: trifluoroacetic anhydride; urea hydrogen peroxide addition compound / chloroform / 2.5 h / 20 °C / Cooling with ice 2.1: trifluoroacetic anhydride / N,N-dimethyl-formamide / 1.33 h / 50 °C / Cooling with ice 2.2: Cooling with ice View Scheme
参考文献
TAISHO PHARMACEUTICAL CO., LTD; NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: US2011/237791 A1, 2011 ;
