(R)-1-Boc-4-Cbz-2-甲基哌嗪合成路线 （共 2 条）
反应条件
1: rac-2-methylpiperazine; benzyl chloroformate in dichloromethane T=0 - 20°C; 3 h; 2: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 167 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C;
参考文献
US2010/35883 A1, ;
Page/Page column 86 ;
