1-苄氧羰基-3-羟基氮杂环丁烷合成路线 （共 5 条）
反应条件
1: 3-hydroxy-1-azetidine hydrochloride With potassium carbonate in tetrahydrofuran; water T=20 - 25°C; 0.5 h; 2: benzyl chloroformate in tetrahydrofuran; water T=0 - 25°C;
参考文献
RIB-X PHARMACEUTICALS, INC.; HANSELMANN, Roger; REEVE, Maxwell, M.; JOHNSON, Graham
Patent: WO2010/36329 A2, 2010 ;
Location in patent: Page/Page column 16-17; 21 ;
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C; 60.5 h; Inert atmosphere;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CONNOLLY, Stephen; EBDEN, Mark, Richard; LANGER, Thomas; STEVEN, Alan, Robert; STEWART, Craig, Robert; TOMLIN, Paula, Margaret; WALTERS, Iain, Alastair, Stewart; WILLIAMS, Andrew, John
Patent: WO2013/8002 A1, 2013 ;
Location in patent: Page/Page column 48; 49 ;
反应条件
triethylamine; palladium monocarbide in methanol; hexane; dichloromethane; ethyl acetate
参考文献
ABBOTT LABORATORIES
Patent: EP416393 A1, 1991 ;
EP 0416393 A1
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 5 h;
参考文献
EXELIXIS, INC.
Patent: WO2008/124085 A2, 2008 ;
Location in patent: Page/Page column 179 ;
WO 2008/124085 A2
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
T=0 - 20°C; Inert atmosphereSchlenk technique;
参考文献
Yi, Jun; Lu, Xi; Sun, Yan-Yan; Xiao, Bin; Liu, Lei
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12409 - 12413
Angew. Chem., 2013 , vol. 125, # 47 p. 12635 - 12639,5
