1: 1-amino-5-hydroxypentane With potassium hydroxide in dimethyl sulfoxide T=40°C; 0.333333 h; 2: Clterpy in dimethyl sulfoxide T=40°C; 2.5 h;

potassium hydroxide in dimethyl sulfoxide T=60°C; 48 h;

NH4PF6; NiCl2((PPh3)P)2; sodium cyanide; triphenylphosphine; zinc 1.) DMF, room temp., 8h, 2.) MeCN, H2O, reflux, 1h; Yield given. Multistep reaction;

1: sodium hydrosulfide monohydrate / N,N-dimethyl-formamide / 4 h / |Inert atmosphere; |Schlenk technique; |Reflux 2: potassium carbonate / acetonitrile / 2 h / 80 - 85 °C / |Schlenk technique; |Inert atmosphere; |Molecular sieve 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / |Schlenk technique; |Inert atmosphere View Scheme

1: sodium hydrosulfide monohydrate / N,N-dimethyl-formamide / 4 h / |Inert atmosphere; |Schlenk technique; |Reflux 2: potassium carbonate / acetonitrile / 2 h / 80 - 85 °C / |Schlenk technique; |Inert atmosphere; |Molecular sieve View Scheme

potassium hydroxide in dimethyl sulfoxide T=70°C; 27 h; Inert atmosphere;