1: Nα-tert-Butyloxycarbonyl-O-benzylhydroxylamine With sodium hydride; sodium iodide in DMF (N,N-dimethyl-formamide) T=20°C; 0.25 h; 2: 4-chloro-valeronitrile in DMF (N,N-dimethyl-formamide) T=85°C; 3.5 h;

sodium hydride; sodium iodide in N,N-dimethyl-formamide Substitution;

ammonia; hydrogen; nickel in methanol Catalytic hydrogenation;