1: 5-hexynyl alcohol With 1H-imidazole in dichloromethane T=0°C; 0.166667 h; 2: tert-butylchlorodiphenylsilane in dichloromethane T=0 - 20°C; 17 h;

1H-imidazole; 5-hexynyl alcohol in DMF (N,N-dimethyl-formamide) T=20°C; 4 h;

1,8-diazabicyclo[5.4.0]undec-7-ene in water; acetonitrile T=60°C; 6 h;

Au(Ph3P)+NTf2-; sulfuric acid; water in methanol T=20°C; 24 h; Inert atmosphere;

AuNTf2(SPhos); water in methanol T=20°C; Inert atmosphere;

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere 1.2: 3.5 h / -78 - 20 °C / Inert atmosphere 2.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran; n-heptane / 1 h / 0 - 65 °C / Inert atmosphere; Darkness 2.2: 0.25 h / -78 °C / Inert atmosphere 3.1: tert.-butyl lithium / diethyl ether; pentane / 0.08 h / -78 °C / Inert atmosphere 3.2: 0.67 h / 0 °C / Inert atmosphere 3.3: 3.5 h / 0 - 20 °C / Inert atmosphere 4.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 20 °C / Inert atmosphere 5.1: n-butyllithium; chloro-trimethyl-silane; triethylamine; diisopropylamine / tetrahydrofuran; hexanes / -78 - 20 °C / Inert atmosphere 5.2: 120 °C / Inert atmosphere 6.1: methanol; diethyl ether; benzene / 1.5 h / 6 - 20 °C / Inert atmosphere 7.1: pyridine; hydrogen fluoride / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere 8.1: pyridinium chlorochromate / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere; Celite 9.1: toluene / 110 °C / Inert atmosphere; Molecular sieve; Sealed tube 9.2: 5.58 h / 0 - 20 °C / Molecular sieve 10.1: PHT / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere 10.2: 12 h / 20 °C / Inert atmosphere 11.1: sodium tetrahydroborate / isopropyl alcohol / 77 h / 20 - 50 °C / Inert atmosphere View Scheme

1: With zirconocene dichloride; diisobutylaluminium hydride in tetrahydrofuran; hexane T=0 - 20°C; 2 h; 2: With N-iodo-succinimide in tetrahydrofuran; hexane T=-78°C; 0.5 h;

1.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere; Molecular sieve 1.2: 5 h / 0 °C / Inert atmosphere; Molecular sieve 2.1: sodium tetrahydroborate; hydrogen; nickel diacetate; ethylenediamine / methanol / 20 °C / Inert atmosphere 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere 4.2: Inert atmosphere 5.1: chromium(VI) oxide; periodic acid / water; acetonitrile / 0 °C 6.1: methanol; diethyl ether / 0.33 h / 0 °C / Inert atmosphere View Scheme

1.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere; Molecular sieve 1.2: 5 h / 0 °C / Inert atmosphere; Molecular sieve 2.1: sodium tetrahydroborate; hydrogen; nickel diacetate; ethylenediamine / methanol / 20 °C / Inert atmosphere 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere 4.2: Inert atmosphere 5.1: chromium(VI) oxide; periodic acid / water; acetonitrile / 0 °C View Scheme