(2S,3R)-3-氨基-2-羟基-4-苯基丁酸盐酸盐合成路线 （共 15 条）
反应条件
hydrogenchloride in ethyl acetate T=80 - 100°C; 14 h;
参考文献
Matsuda, Fuyuhiko; Mtsumoto, Teruyo; Ohsaki, Masako; Ito, Yoshio; Terashima, Shiro
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 2 p. 360 - 365
反应条件
hydrogenchloride; sodium hydroxide 1) EtOH, reflux;
参考文献
Norman; Morris
Tetrahedron Letters, 1992 , vol. 33, # 45 p. 6803 - 6806
反应条件
1: 93 percent / imidazole / dimethylformamide / Ambient temperature 2: 80 percent / DIBAL / hexane; diethyl ether / 0.33 h / -78 °C 3: MgSO4 / toluene / 0 °C 4: Et3N / CH2Cl2 / Ambient temperature 5: 70 percent / HCl gas / 1) rt, overnight, 2) 60 deg C, 3 h 6: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 7: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 8: 6 M HCl / 4.5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
反应条件
1: MgSO4 / toluene / 0 °C 2: Et3N / CH2Cl2 / Ambient temperature 3: 70 percent / HCl gas / 1) rt, overnight, 2) 60 deg C, 3 h 4: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 5: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 6: 6 M HCl / 4.5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
反应条件
1: 80 percent / DIBAL / hexane; diethyl ether / 0.33 h / -78 °C 2: MgSO4 / toluene / 0 °C 3: Et3N / CH2Cl2 / Ambient temperature 4: 70 percent / HCl gas / 1) rt, overnight, 2) 60 deg C, 3 h 5: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 6: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 7: 6 M HCl / 4.5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
反应条件
1: Et3N / CH2Cl2 / Ambient temperature 2: 70 percent / HCl gas / 1) rt, overnight, 2) 60 deg C, 3 h 3: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 4: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 5: 6 M HCl / 4.5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
反应条件
1: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 2: 6 M HCl / 4.5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
反应条件
1: 70 percent / HCl gas / 1) rt, overnight, 2) 60 deg C, 3 h 2: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 3: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 4: 6 M HCl / 4.5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
反应条件
1: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 2: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 3: 6 M HCl / 4.5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
反应条件
hydrogenchloride T=100°C; 4.5 h;
参考文献
Tetrahedron, , vol. 48, # 10 p. 1853 - 1868
