(2S,3R)-3-氨基-2-羟基-4-苯基丁酸盐酸盐合成路线 （共 15 条）
反应条件
1: 100 percent / SOCl2 2: 89 percent / tetrahydrofuran / 1 h / 0 °C 3: 98 percent / LiCl, NaBH4 / ethanol / 17 h / Ambient temperature 4: 81 percent / SO3*Py, Et3N / toluene; dimethylsulfoxide / 0.33 h / Ambient temperature 5: 100 percent / benzyltributylammonium chloride / CH2Cl2; H2O / 3 h / 0 °C 6: 50 percent / aq. HCl / ethyl acetate / 14 h / 80 - 100 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 2 p. 360 - 365
反应条件
1: 89 percent / tetrahydrofuran / 1 h / 0 °C 2: 98 percent / LiCl, NaBH4 / ethanol / 17 h / Ambient temperature 3: 81 percent / SO3*Py, Et3N / toluene; dimethylsulfoxide / 0.33 h / Ambient temperature 4: 100 percent / benzyltributylammonium chloride / CH2Cl2; H2O / 3 h / 0 °C 5: 50 percent / aq. HCl / ethyl acetate / 14 h / 80 - 100 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 2 p. 360 - 365
反应条件
1: 100 percent / benzyltributylammonium chloride / CH2Cl2; H2O / 3 h / 0 °C 2: 50 percent / aq. HCl / ethyl acetate / 14 h / 80 - 100 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 2 p. 360 - 365
反应条件
1: 81 percent / SO3*Py, Et3N / toluene; dimethylsulfoxide / 0.33 h / Ambient temperature 2: 100 percent / benzyltributylammonium chloride / CH2Cl2; H2O / 3 h / 0 °C 3: 50 percent / aq. HCl / ethyl acetate / 14 h / 80 - 100 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 2 p. 360 - 365
反应条件
1: 98 percent / LiCl, NaBH4 / ethanol / 17 h / Ambient temperature 2: 81 percent / SO3*Py, Et3N / toluene; dimethylsulfoxide / 0.33 h / Ambient temperature 3: 100 percent / benzyltributylammonium chloride / CH2Cl2; H2O / 3 h / 0 °C 4: 50 percent / aq. HCl / ethyl acetate / 14 h / 80 - 100 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 2 p. 360 - 365
