N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=60°C; 18 h;

triethylamine in diethyl ether; acetonitrile 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h;

1: 99 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature 2: 94 percent / Et3N / acetonitrile; diethyl ether / 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h View Scheme

triethylamine in acetonitrile 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h;

sodium hydroxide 1.) 60 deg C, 15 min, 2.) RT, 1 h;