4-叔丁氧羰基氨基-1-甲基-1H-咪唑-2-甲酸合成路线 （共 10 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine in DMF (N,N-dimethyl-formamide) T=60°C; 3 h; 2: With sodium hydroxide in methanol T=60°C; 1 h; 3: With hydrogenchloride in methanol; water T=0°C; pH=2;
参考文献
UNIVERSITY OF WESTERN SYDNEY
Patent: WO2005/33077 A1, 2005 ;
Location in patent: Page/Page column 54 ;
反应条件
potassium tert-butylate; water in tetrahydrofuran T=20°C; 1 h;
参考文献
Jaramillo, David; Liu, Qi; Aldrich-Wright, Janice; Tor, Yitzhak
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8151 - 8153
反应条件
sodium hydroxide 1.) 60 deg C, 15 min, 2.) RT, 1 h;
参考文献
Grehn, Leif; Ding, Lu; Ragnarsson, Ulf
Acta Chemica Scandinavica, 1990 , vol. 44, # 1 p. 67 - 74
反应条件
1: N,N-diisopropylethylamine / dimethylformamide / 18 h / 60 °C 2: aq. 1 M NaOH / 3 h / 60 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 118, # 26 p. 6141 - 6146
反应条件
1: 70 percent / methanol / 3 h 2: 91 percent / hydrogen / Pd/C / methanol / 31 h 3: 87 percent / potassium tert-butoxide; H2O / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 91 percent / hydrogen / Pd/C / methanol / 31 h 2: 87 percent / potassium tert-butoxide; H2O / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 65 percent / HNO3; H2SO4; acetic anydride / 24 h / 0 - 20 °C 2: 70 percent / methanol / 3 h 3: 91 percent / hydrogen / Pd/C / methanol / 31 h 4: 87 percent / potassium tert-butoxide; H2O / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 99 percent / H2 / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature 2: 94 percent / Et3N / acetonitrile; diethyl ether / 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h 3: 94 percent / aq. NaOH / 1.) 60 deg C, 15 min, 2.) RT, 1 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 44, # 1 p. 67 - 74
反应条件
1: 94 percent / Et3N / acetonitrile; diethyl ether / 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h 2: 94 percent / aq. NaOH / 1.) 60 deg C, 15 min, 2.) RT, 1 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 44, # 1 p. 67 - 74
反应条件
1: 94 percent / Et3N / acetonitrile; diethyl ether / 1.) 40 deg C, 10 min, 2.) RT, 25 h, 3.) 40 deg C, 4 h 2: 94 percent / aq. NaOH / 1.) 60 deg C, 15 min, 2.) RT, 1 h View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 44, # 1 p. 67 - 74
