1.1: tetra-(n-butyl)ammonium iodide / tetrahydrofuran / -15 - -10 °C 1.2: 18.5 h / -15 - 20 °C 2.1: ozone / dichloromethane / -70 °C / Inert atmosphere 2.2: -70 - 20 °C 3.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol; tetrahydrofuran / 4 h / 20 °C 4.1: methylamine / water; tetrahydrofuran / 5 - 23 °C View Scheme

Multi-step reaction with 2 steps 1: sodium hydride / tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 18.5 h / -15 - 20 °C2: ozone / dichloromethane / -70 °C