反应条件
1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / -78 - 0 °C / Inert atmosphere
2.1: 4-(N,N-dimethlyamino)pyridine; triethylamine; methanesulfonyl chloride / dichloromethane / 1.5 h
2.2: 1 h / 70 °C
3.1: sodium periodate; water / ruthenium trichloride / acetonitrile / 5 h / 0 °C
4.1: N,N-dimethyl-formamide; water / 0.25 h
4.2: 0.17 h / 10 °C
4.3: 1 h / 0 °C
5.1: triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
5.2: 10 h
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; CHANG, Ji-Yeon; LEE, Hyun Seung; KIM, Dong Jun; KO, Myoung-Sil; KIM, Nam Du; CHANG, Young Kil; KIM, Maeng Sup
Patent: WO2011/102640 A2, 2011 ;