6-甲基-6,11-二氢-11-((N,N-二甲基氨基)乙酰基)二苯并(c,f)-(1,2,5)-硫杂二氮杂卓5,5-二氧化物合成路线 （共 9 条）
反应条件
in water; acetone 48 h; Ambient temperature;
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
反应条件
1: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating 2: 80 percent / 2 h / Heating 3: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
反应条件
1: iron, acetic acid / 1 h / Heating 2: acetic acid 3: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature 4: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating 5: 80 percent / 2 h / Heating 6: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
反应条件
1: acetic acid 2: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature 3: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating 4: 80 percent / 2 h / Heating 5: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
反应条件
1: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature 2: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating 3: 80 percent / 2 h / Heating 4: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
反应条件
1: pyridine / tetrahydrofuran / 2 h / Heating 2: iron, acetic acid / 1 h / Heating 3: acetic acid 4: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature 5: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating 6: 80 percent / 2 h / Heating 7: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
反应条件
1: pyridine / tetrahydrofuran / 2 h / Heating 2: iron, acetic acid / 1 h / Heating 3: acetic acid 4: 92 percent / NaOCH3 / methanol / 24 h / Ambient temperature 5: 91 percent / K2CO3, copper, CuBr / dimethylformamide / 8 h / Heating 6: 80 percent / 2 h / Heating 7: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
参考文献
A. Menarini Industrie Farmaceutiche Riunite
Patent: US5011833 A1, 1991 ;
反应条件
1: 80 percent / 2 h / Heating 2: 70 percent / acetone; H2O / 48 h / Ambient temperature View Scheme
参考文献
Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1356 - 1362
