1: 4-methyl-benzaldehyde With 3,3'-(1,4-phenylenebis(methylene))bis(5-(2-hydroxyethyl)-4-methylthiazol-3-ium) bromide; triethylamine in ethanol T=20°C; Stetter reaction; 0.166667 h; 2: Benzalacetophenone in ethanol T=70°C; Stetter reaction; 15 h;

3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; isopropyl alcohol in tetrahydrofuran T=70°C; 12 h;

samarium in N,N-dimethyl-formamide T=25°C; Michael addition; 1.5 h; Inert atmosphere;

hydrogenchloride in ethanol 0.166667 h; Heating;