2-氯甲基-3-甲基-4-(2,2,2-三氟乙氧基)吡啶合成路线 （共 5 条）
反应条件
thionyl chloride in dichloromethane T=25°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
1: With p-toluenesulfonyl chloride in toluene T=50°C; 0.5 h; 2: With triethylamine in toluene T=65°C; 1.5 h;
参考文献
Synthetic Communications, , vol. 32, # 8 p. 1211 - 1217
反应条件
1: 2N aq. NaOH / methanol / 2 h / 25 °C 2: SOCl2 / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
sodium hydroxide in water Flow reactor;
参考文献
Organic Process Research and Development, , vol. 17, # 10 p. 1272 - 1276
反应条件
1: sodium hydroxide / water / |Flow reactor 2: sodium hypochlorite; sodium hydroxide / water; acetonitrile / |Flow reactor; |Large scale View Scheme
参考文献
Reddy, Gunupati Sharathchandra; Reddy, Narra Santosh; Manudhane, Kushal; Rama Krishna, Medisetti Venkata; Ramachandra, Kopparapu Janardana Sarma; Gangula, Srinivas
Organic Process Research and Development, 2013 , vol. 17, # 10 p. 1272 - 1276
