5-氯-1-甲基-3-(三氟甲基)吡唑-4-羰醛合成路线 （共 7 条）
反应条件
trichlorophosphate T=0 - 20°C; 1 h; Heating / reflux;
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY CO., LTD.
Patent: EP1405853 A1, 2004 ;
Location in patent: Page 83-84 ;
反应条件
sodium hydroxide; trichlorophosphate in N,N-dimethyl-formamide
反应条件
trichlorophosphate Vilsmeier-Haack reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 48, # 2 p. 389 - 396
反应条件
sodium tetrahydroborate in methanol T=0 - 20°C; 2 h;
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY CO., LTD.
Patent: EP1405853 A1, 2004 ;
Location in patent: Page 84 ;
反应条件
1: potassium permanganate 2: thionyl chloride View Scheme
参考文献
Wu, Lintao; Song, Baoan; Bhadury, Pinaki S.; Yang, Song; Hu, Deyu; Jin, Linhong
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 389 - 396
反应条件
triethylamine in 1,2-dichloro-ethane T=20 - 80°C; 14 h;
参考文献
KALYPSYS, INC.
Patent: WO2007/84868 A2, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/084868 A2
反应条件
sodium hydroxide; dihydrogen peroxide in water T=40 - 50°C; 2 h;
参考文献
Yagihara, Tomio; Imagawa, Tsutomu; Suga, Shigemi; Hatano, Masami; Shibata, Yasushi; Ookuchi, Tetsushi; Kasahara, Isamu
Patent: US2004/19221 A1, 2004 ;
Location in patent: Page 7 ;
