L-7-羟基-1,2,3,4-四氢异喹啉-3-羧酸合成路线 （共 4 条）
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol; water T=25°C; P=2068.6 Torr; 3 h;
参考文献
Verschueren; Toth; Tourwe; Lebl; Van Binst; Hruby
Synthesis, 1992 , # 5 p. 458 - 460
反应条件
1: 48 percent / conc. HCl / 1,2-dimethoxy-ethane / 18.5 h / 72 °C 2: 73 percent / hydrogen, Et3N / 10 percent Pd-C / ethanol; H2O / 3 h / 25 °C / 2068.6 Torr View Scheme
参考文献
Synthesis, , # 5 p. 458 - 460
反应条件
sodium carbonate in 1,4-dioxane Acylation; 16 h;
参考文献
Page; McClory; Mischki; Schmidt; Butterworth; St-Onge; Labarre; Payza; Brown
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 2 p. 167 - 170
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water 12 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; PEREZ, Heidi L.; STANG, Erik M.; KIM, Kyoung S.
Patent: WO2013/192286 A1, 2013 ;
Location in patent: Paragraph 00163 ;
