iodine in methanol; water

1: 95 percent / Ti(IV) complex with (R)-(-)-binaphthyl amino alcohol 2: 100 percent / LiOH / methanol; H2O 3: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 4: 93 percent / LiOH 5: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 6: 84 percent / I2 / methanol; H2O View Scheme

1: 74 percent / (COCl)2, DMSO, Et3N 2: 95 percent / Ti(IV) complex with (R)-(-)-binaphthyl amino alcohol 3: 100 percent / LiOH / methanol; H2O 4: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 5: 93 percent / LiOH 6: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 7: 84 percent / I2 / methanol; H2O View Scheme

1: 91 percent / DIBAL 2: 74 percent / (COCl)2, DMSO, Et3N 3: 95 percent / Ti(IV) complex with (R)-(-)-binaphthyl amino alcohol 4: 100 percent / LiOH / methanol; H2O 5: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 6: 93 percent / LiOH 7: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 8: 84 percent / I2 / methanol; H2O View Scheme

1: 78 percent / Cs2CO3 2: 91 percent / DIBAL 3: 74 percent / (COCl)2, DMSO, Et3N 4: 95 percent / Ti(IV) complex with (R)-(-)-binaphthyl amino alcohol 5: 100 percent / LiOH / methanol; H2O 6: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 7: 93 percent / LiOH 8: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 9: 84 percent / I2 / methanol; H2O View Scheme

1: 95 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 2: Et2NH 3: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 4: Et2NH 5: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 6: 97 percent 7: 96 percent / DABCO, Et2NH 8: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 9: 93 percent / LiOH 10: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 11: 84 percent / I2 / methanol; H2O View Scheme

1: Et2NH 2: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 3: Et2NH 4: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 5: 97 percent 6: 96 percent / DABCO, Et2NH 7: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 8: 93 percent / LiOH 9: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 10: 84 percent / I2 / methanol; H2O View Scheme

1: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 2: 93 percent / LiOH 3: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 4: 84 percent / I2 / methanol; H2O View Scheme

1: Et2NH 2: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 3: 97 percent 4: 96 percent / DABCO, Et2NH 5: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 6: 93 percent / LiOH 7: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 8: 84 percent / I2 / methanol; H2O View Scheme

1: 97 percent 2: 96 percent / DABCO, Et2NH 3: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 4: 93 percent / LiOH 5: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 6: 84 percent / I2 / methanol; H2O View Scheme