1-Boc-吲哚-3-乙酸合成路线 （共 5 条）
反应条件
1: HCl / 0.17 h 2: DMAP / CH2Cl2 3: aq. LiOH / methanol / 0.17 h View Scheme
参考文献
Jasys, V. John; Kelbaugh, Paul B.; Nason, Deane M.; Phillips, Douglas; Rosnack, Kenneth J.; Saccomano, Nicholas A.; Stroh, Justin G.; Volkmann, Robert A.
Journal of the American Chemical Society, 1990 , vol. 112, # 18 p. 6696 - 6704
反应条件
1: 91 percent / 4-(N,N-dimethylamino)pyridine / acetonitrile / 0.25 h 2: 48 percent / sodium 2-ethylhexanoate, triphenylphosphine, tetrakis(triphenylphosphine)palldium / CH2Cl2; ethyl acetate / 1 h View Scheme
参考文献
Jasys, V. John; Kelbaugh, Paul B.; Nason, Deane M.; Phillips, Douglas; Rosnack, Kenneth J.; Saccomano, Nicholas A.; Stroh, Justin G.; Volkmann, Robert A.
Journal of the American Chemical Society, 1990 , vol. 112, # 18 p. 6696 - 6704
反应条件
1: 83 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 4 h / 20 °C 2: 100 percent Chromat. / Bu4NF / tetrahydrofuran / 7 h / Heating View Scheme
参考文献
Hone; Payne
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6149 - 6152
反应条件
1: 83 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 4 h / 20 °C 2: 100 percent Chromat. / Bu4NF / tetrahydrofuran / 7 h / Heating View Scheme
参考文献
Jacquemard, Ulrich; Beneteau, Valerie; Lefoix, Myriam; Routier, Sylvain; Merour, Jean-Yves; Coudert, Gerard
Tetrahedron, 2004 , vol. 60, # 44 p. 10039 - 10047
反应条件
1: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide (DCC) / 1.) CH2Cl2, 3 h, 2.) RT, 12 h 2: 1.) 85percent 3-chloroperoxybenzoic acid, 2.) NaBH3CN / 1.) acetone, 0 deg C, 30 min, 2.) acetic acid, 12 h 3: 95 percent / trifluoroacetc acid / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Jasys, V. John; Kelbaugh, Paul B.; Nason, Deane M.; Phillips, Douglas; Rosnack, Kenneth J.; Saccomano, Nicholas A.; Stroh, Justin G.; Volkmann, Robert A.
Journal of the American Chemical Society, 1990 , vol. 112, # 18 p. 6696 - 6704
