5-溴-1-(三异丙基硅基)-1H-吲哚合成路线 （共 7 条）
反应条件
1: 5-Bromo-1H-indole With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.333333 h; 2: triisopropylsilyl chloride in tetrahydrofuran T=-78 - 20°C; 1.33333 h;
参考文献
Roche Palo Alto LLC
Patent: US2009/318493 A1, 2009 ;
Location in patent: Page/Page column 22 ;
US 20090318493 A1
反应条件
1: 5-Bromo-1H-indole With sodium hydride in tetrahydrofuran T=0 - 20°C; 1 h; 2: triisopropylsilyl chloride in tetrahydrofuran T=0 - 20°C;
参考文献
PLEXXIKON, INC.
Patent: WO2005/9958 A1, 2005 ;
Location in patent: Page 97-98 ;
WO 2005/009958 A1
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5700809 A1, 1997 ;
US 5700809 A
反应条件
NaH in water; N,N-dimethyl-formamide
参考文献
Havez, Sophie Elisabeth
Patent: US2003/73832 A1, 2003 ;
US 20030073832 A1
反应条件
triethylamine; palladium diacetate; 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane T=80°C; 2 h;
参考文献
Helvetica Chimica Acta, , vol. 89, # 5 p. 936 - 946
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether; water; pentane
参考文献
SmithKline Beecham plc
Patent: US5637593 A1, 1997 ;
反应条件
tert.-butyl lithium in ethanol; hexane
参考文献
Bristol-Myers Squibb Company
Patent: US5468768 A1, 1995 ;
US 5468768 A
