2: 1.) Bu2BOTf, (i-Pr)2NEt, 2.) NBS / 1.) CH2Cl2, 0 deg C -> r.t., 1.5 h, 2.) CH2Cl2, -78 deg C, 4 h 3: (n-Bu)4NN3 / acetonitrile / 6 h 4: aq. H2O2, LiOH / tetrahydrofuran / 0.75 h / 0 °C 5: H2, 0.2 N aq. HCl / 10percent Pd/C / 15 h / 760 Torr / Ambient temperature 6: 48percent aq. HBr / acetic acid / 6 h / Heating View Scheme

1: H2, 0.2 N aq. HCl / 10percent Pd/C / 15 h / 760 Torr / Ambient temperature 2: 48percent aq. HBr / acetic acid / 6 h / Heating View Scheme

ammonium sulfate; ammonium hydroxide; pyridoxal 5'-phosphate; ammonium chloride 168 h; tyrosine phenol-lyase;